ZenToks Publication

Chapter 6

Quadriparesis Secondary to Hypokalemia in Tenofovir Induced Fanconi Syndrome: A Case Report

Abstract/Preface

Tenofovir disoproxil fumarate (TDF) is an extensively used antiretroviral medicine in the treatment of HIV, however its long-term usage is associated with kidney damage, mainly Fanconi syndrome. Proximal tubular dysfunction is a feature of this syndrome that causes the kidneys to lose vital electrolytes like potassium. Fanconi syndrome frequently results in hypokalemia, and extreme potassium deficiency can cause neuromuscular dysfunction, including quadriparesis, a disorder characterized by weakness or paralysis in all four limbs. Here we describe a case of 50 years old male patient presented with sudden onset of decreased responsiveness with known case of recurrent hypokalemia and hypoglycemia and diagnosed as Tenofovir induced Fanconi syndrome with Quadriparesis secondary to Hypokalemia.